in Animals
- Clostridium septicum, the cause of malignant edema, is found in soil and intestinal contents of all species of animals. Infection generally occurs via contamination of wounds. Clinical signs develop within 2 days, including systemic signs (eg, fever) and localized swellings in muscles and intermuscular connective tissues. A fatal toxemia often results. Confirmation of diagnosis is by laboratory testing. Treatment consists of antimicrobials and supportive therapy. Control is via immunization using a bacterin, often in a multivalent vaccine.
- C septicum also causes Braxy in sheep, a highly fatal infection characterized by toxemia and inflammation of the abomasal wall. This disease seems to be confined mostly to European sheep fed on “frosted” pasture.